Read e-book online Antiplatelet Therapy in Cardiovascular Disease PDF

By Ron Waksman, Paul A. Gurbel, Michael A. Gaglia Jr.

ISBN-10: 1118275756

ISBN-13: 9781118275757

ISBN-10: 1118493982

ISBN-13: 9781118493984

ISBN-10: 1118494016

ISBN-13: 9781118494011

ISBN-10: 1118494024

ISBN-13: 9781118494028

Edited by way of one of many world's major interventional cardiologists and educators, this new publication is created with a watch on giving the reader an exceptional, functional and clinically-focused figuring out of this crucial category of gear, from uncomplicated technological know-how to a clear-headed dialogue of advanced subject matters akin to blend treatments, drug-drug interactions, and platelet resistance.

This vital new book:

  • Begins with a concise yet thorough dialogue of platelet biology and pathophysiology in order that readers know how those treatments paintings and why they could additionally produce this sort of assorted diversity of problems, from minor gastrointestinal dissatisfied, to in all likelihood life-threatening stipulations similar to neutropenia, a serious scarcity of white blood cells.
  • Thoroughly covers platelet functionality checking out, together with new, novel techniques.
  • Clarifies present best-practices in regards to the use of antiplatelet brokers in either continual and acute cardiovascular disease
  • Reviews of all kinds of antiplatelet brokers – from aspirin to lately licensed medicinal drugs – together with symptoms, medical results, and part effects/complications

Written via a world who's-who of specialists within the box, Antiplatelet treatment additionally comprises a complete part overlaying using antiplatelet medicines in PCIs, together with percutaneous valve fix, which makes this article really necessary to Interventional Cardiologists.

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Additional info for Antiplatelet Therapy in Cardiovascular Disease

Sample text

The demonstration that high doses of aspirin blunted the antithrombotic effects of the P2Y12 inhibitor ticagrelor in the PLATO trial [9] is consistent with this hypothesis. Role of P2Y12 in platelet thrombus formation in vitro and in vivo Several studies reported the important role of the P2Y12 receptor in platelet thrombus formation and stabilization on collagen-coated surfaces or ruptured atherosclerotic plaques under flow conditions [4]. Studies of P2Y12 KO mice and of wild-type animals treated with P2Y12 antagonists or inhibitors, using different models of experimental arterial and venous thrombosis, have clearly demonstrated the important role of this receptor in thrombogenesis in vivo.

Alternative sources of arachidonic acid are arachidonylethanolamide (anandamide) and 2-arachidonylglycerol [2]. COX activity requires an activating hydroperoxide to generate a tyrosyl radical at Tyr385, which is essential to initiate catalytic activity. Thus, platelet TXA2 formation also depends on the concentration of Antiplatelet Therapy in Cardiovascular Disease, First Edition. Edited by Ron Waksman, Paul A. Gurbel, and Michael A. Gaglia, Jr. © 2014 John Wiley & Sons, Ltd. Published 2014 by John Wiley & Sons, Ltd.

And Rimon, G. (2001) Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H sythase-1 inhibition by nonsteroidal anti-inflammatory drugs. European Journal of Pharmacology, 412, 101–108. C. et al. (2001) Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. New England Journal of Medicine, 345, 1809–1817. , Park, R. and Ruijne, N. (2008) The antiplatelet effect of six non-steroidal anti-inflammatory drugs and their pharmacodynamic interaction with aspirin in healthy volunteers.

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Antiplatelet Therapy in Cardiovascular Disease by Ron Waksman, Paul A. Gurbel, Michael A. Gaglia Jr.


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