By Mancia Giuseppe
Due to the fact that angiotensin II is among the such a lot effective vasoconstrictors and a tremendous stimulus for the secretion of aldosterone from the adrenal gland, the advance of of angiotensin II inhibitors is a crucial step in regulating blood strain. This category of drug is well-tolerated by way of pateints and those medications have the extra virtue over ACE inhibitors in that they're now not linked to cough. simply because so much medications may be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive impression together with diuretics, they're a welcome healing instrument within the therapy of high blood pressure. This moment variation builds at the good fortune of the 1st and brings to the reader all of the most modern advancements, scientific trial info, and the contributors's own views whilst treating sufferers with angiotensin II receptors antagonists.
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Additional info for Angiotensin II receptor antagonists : current perspectives
556 44 7/3/06 4:06 pm Page 44 Stimulation of AT2 receptors 39. Wu L, Iwai M, Nakagami H et al. Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammationinduced vascular injury. Circulation 2001; 104:2716–21. 40. Akishita M, Iwai M, Wu L et al. Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice. Circulation 2000; 102:1684–9. 41.
Furthermore, it was shown that blood pressure reduction in SHRs was associated with an increase in AT2R protein expression in resistance arteries. g. fibrotic indices). The partly contradictory observations could also indicate that the role of the AT2R per se is neither purely ‘good’ nor ‘evil’. 3). 97 Clinically applicable AT2R agonists might also address the problem that the role of the AT2R under ARB therapy is difficult to examine in the human situation. g. mRNA quantification in different organs or effects of simultanous AT2R blockade) were obtained in human clinical studies.
Up-regulation vs down-regulation) of this regulation depends on the presence or absence of EGF in this study. 90 AT1R-independent effects of ARBs Recently, our group was able to identify a novel mechanism of ARB action. 91 This observation could explain the insulin-sensitizing effects of ARBs. Furthermore, AT2R activation can induce mRNA, protein, and activity of a PPAR-␥ isoform in pheochromocytoma cells,92 indicating synergistic effects of AT2R activation and PPAR-␥-stimulating ARBs. g. e. g.
Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe