Gaetano Santulli's Angiogenesis: Insights from a Systematic Overview PDF

By Gaetano Santulli

ISBN-10: 1626181144

ISBN-13: 9781626181144

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Cao R, Brakenhielm E, Pawliuk R et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 2003;9:604-13. Iruela-Arispe ML. The Cell Biology of Angiogenesis. Angiogenesis 2005;1:1-30. Djonov V, Schmid M, Tschanz SA, Burri PH. Intussusceptive angiogenesis: its role in embryonic vascular network formation. Circ Res 2000;86:286-92. Choi K. The hemangioblast: a common progenitor of hematopoietic and endothelial cells. J Hematother Stem Cell Res 2002;11:91-101.

Whereas the endothelial tubes that make up primitive vascular plexus are morphologically indistinguishable, mature arteries and veins differ in their arrangement of extracellular matrix, smooth muscle cells, and other supporting cells that provide specialized mechanical and physiological properties. Thus, it is conceivable that the formation of arterial and venous networks might differ from one another. Indeed, it appears that during differentiation, endothelial cells become committed to either arterial our venous identities.

PlGF contributes to this angiogenic switch via several 16 Evangeli Lampri and Elli Ioachim mechanisms. By displacing VEGF from VEGFR-1, PlGF is expected to make more VEGF available to bind and activate VEGFR-2 and thereby enhance VEGF-driven angiogenesis. [77] This originally proposed mechanism is still correct, but recent evidence indicates that it is not the sole mechanism whereby PlGF and VEGFR-1 enhance pathological angiogenesis. Indeed, PlGF contributes to the angiogenic switch in pathological conditions, by affecting, directly and indirectly, multiple cell types.

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Angiogenesis: Insights from a Systematic Overview by Gaetano Santulli


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