By Carolyn A. Staton, Claire Lewis, Roy Bicknell
Chapter 1 Endothelial cellphone Biology (pages 1–38): Femke Hillen, Veerle Melotte, Judy R. van Beijnum and Arjan W. Griffioen
Chapter 2 Endothelial phone Proliferation Assays (pages 39–50): Wen?Sen Lee
Chapter three Endothelial mobilephone Migration Assays (pages 51–64): Christos Polytarchou, Maria Hatziapostolou and Evangelia Papadimitriou
Chapter four Tubule Formation Assays (pages 65–87): Ewen J. Smith and Carolyn A. Staton
Chapter five Modelling the consequences of the Haemodynamic setting on Endothelial phone Responses proper to Angiogenesis (pages 89–103): Gerard B. Nash and Stuart Egginton
Chapter 6 entire or Partial Vessel Outgrowth Assays (pages 105–121): Cindy H. Chau and William D. Figg
Chapter 7 Assaying Endothelial–Mural phone Interactions (pages 123–137): Melissa ok. Nix and Karen okay. Hirschi
Chapter eight Assays for Membrane and Intracellular Signalling occasions (pages 139–166): Vittorio Tomasi, Cristiana Griffoni, Spartaco Santi, Patrizia Lenaz, Rosa Anna Iorio, Antonio Strillacci and Enzo Spisni
Chapter nine Implantation of Sponges and Polymers (pages 167–182): Silvia P. Andrade, Monica A. N. D. Ferreira and Tai?Ping Fan
Chapter 10 Angiogenesis Assays within the Chick (pages 183–201): Andries Zijlstra, David Mikolon and Dwayne G. Stupack
Chapter eleven Corneal Angiogenesis Assay (pages 203–228): Siqing Shan and Mark W. Dewhirst
Chapter 12 Dorsal Air Sac version (pages 229–238): Sei Yonezawa, Tomohiro Asai and Naoto Oku
Chapter thirteen Chamber Assays (pages 239–263): Michael D. Menger, Matthias W. Laschke and Brigitte Vollmar
Chapter 14 Tumour versions: research of Angiogenesis in vivo (pages 265–291): Sven A. Lang and Oliver Stoeltzing
Chapter 15 Angiomouse: Imageable versions of Angiogenesis (pages 293–310): Robert M. Hoffman
Chapter sixteen thoughts and Advances in Vascular Imaging in Danio Rerio (pages 311–326): Kenna R. generators Shaw and Brant. M. Weinstein
Chapter 17 organic and medical Implications of Recruitment of Stem Cells into Angiogenesis (pages 327–340): Gianluigi Castoldi, Antonio Cuneo and Gian Matteo Rigolin
Chapter 18 equipment for tracking of the Anti?Angiogenic job of brokers in sufferers: Novel Trial layout (pages 341–359): Shannon Smiley, Michael okay. okay. Wong and Shaker A. Mousa
Chapter 19 an outline of present Angiogenesis Assays: selection of Assay, Precautions in Interpretation, destiny requisites and instructions (pages 361–374): Robert Auerbach
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Extra info for Angiogenesis Assays: A Critical Appraisal of Current Techniques
Other antiangiogenic molecules, such as endostatin, angiostatin and thrombospondin, that are natural components of the ECM, can also bind to avb3 and disrupt the endothelial cell– extracellular matrix interactions. , 2003; Stupack and Cheresh, 2004). , 2003). Many matrix components have 8 CH1 ENDOTHELIAL CELL BIOLOGY heparin binding motifs that mediate the interaction with cell surface HSPGs. This group of cell surface adhesion molecules consist of a core protein that is covalently linked to heparin sulphate-type glycosaminoglycan side-chains.
Based on their structure and substrate specificity, they are classified into several subgroups: collagenases, stromelysins, matrilysins, gelatinases and membrane type MMPs. Most of them are secreted as zymogens that will be activated by other MMPs or serine proteinases. After detachment of endothelial cells, MMPs can promote migration and proliferation of endothelial cells. In the initial step of angiogenesis a fibrin gel, a provisional matrix generated from fibrinogen leakage, is polymerized and endothelial cells attach to these provisional matrix components including fibrin, vitronectin, fibronectin, collagen I and thrombin.
The field of angiogenesis started to gain real attention when it was hypothesized that 1) tumours are most vulnerable at the level of their blood supply and 2) because tumours are dependent on angiogenesis, blocking angiogenesis would be a tool for therapeutic intervention (Folkman, 1971). The process of angiogenesis is tightly regulated by positive and negative regulators. The balance between both determines the level of ongoing angiogenesis. A number of angiogenic growth factors and inhibitors are discussed below.
Angiogenesis Assays: A Critical Appraisal of Current Techniques by Carolyn A. Staton, Claire Lewis, Roy Bicknell