Get Alzheimer's Disease: Methods and Protocols (Methods in PDF

By N. M. Hooper

ISBN-10: 0585395071

ISBN-13: 9780585395074

ISBN-10: 0896037371

ISBN-13: 9780896037373

A panel of hugely expert investigators describe intimately their state of the art biochemical, telephone organic, and molecular organic suggestions for learning the molecular foundation of Alzheimer's affliction. those comfortably reproducible, step by step tools specialise in paintings with the amyloid precursor protein and the amyloidogenic peptide A?, but in addition include-with the hot id of presenilin proteins-techniques for selecting the constitution and organic functionality of those proteins. furthermore, there are chapters masking the tau protein and its position in Alzheimer's disorder, in addition to an introductory dialogue of the background of the sickness, its genetic foundation, and the at present on hand and attainable destiny healing brokers. state-of-the-art and vast ranging, Alzheimer's illness: equipment and Protocols presents prepared entry to confirmed, reproducible equipment for elucidating the molecular foundation of this most typical senile dementia.

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Natl. Acad. Sci. USA 83,4913-4917. 15. , Joachim, C. J. (1986) Microtubule-associated protein tau is a major antigenic component of paired helical filaments in Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 83,4044-4048. 16. Lee, V. , Balin, B. , and Trojanowski, J. (1991) A68, a major subunit of paired helical filaments and derivatized froms of normal tau. Science 251, 675-678. 17. Wischik, C. ,Thogersen, H. , Edwards, P. , Runswick, M. , et al. (1988) Isolation of afragment of tau derivedfrom the core of the paired helical filament of Alzheimer disease.

1988) Familial risk of dementia associated with a biologic subtype of Alzheimer’s disease. Arch. Gen. 45,889-893. 14. , Rethore,M. ,andAlperovitch,A. (1989)Absence of familial association between dementia of the Alzheimer type and Down’s syndrome. Am. J. Med. Genet. 33,545-550. 15. Breitner,J. C. S. andFolstein, M. (1984) Familial Alzheimer dementia: aprevalent disorder with specific clinical features. Psychol. 14,63-80. 16. , Meyers, R. , Cupples, L. , et al. (1990) Transmission and age at onset patterns in familial Alzheimer’s disease: evidence of heterogeneity.

Frail, D. E. (1994) Isoform specific binding of apolipoprotein E to b amyloid. J. Biol. Chem. 269, 23,403-23,406. 32. , Smith, J. , Greengard,P. and Gandy, S. (1996) Alzheimer amyloidp peptide forms denaturant resistant complex with type E3 but not typeE4 isoform of apolipoprotein E. Mol. Med. 2, 175-180. 33. Strittmatter, W. , Saunders, A. , Weisgraber,K. , Dong, L. , et al. (1994) Isoform specific interactions of Apolipoprotein E with microtubule associated protein tau: implications for Alzheimer’s disease.

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Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine) by N. M. Hooper


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