New PDF release: Aerosols and the Lung. Clinical and Experimental Aspects

By Stewart W. Clarke

ISBN-10: 0407002650

ISBN-13: 9780407002654

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Additional resources for Aerosols and the Lung. Clinical and Experimental Aspects

Example text

T h e volume of mucus produced daily by a normal h u m a n tracheobronchial tree is not known with certainty. Based on studies in subjects with tracheostomy, the daily volume was found to be 7 and 2 1 m l (Toremalm, 1960). It is possible that this Tracheobronchial secretion 31 volume is an overestimation since the airways of these subjects are not entirely normal and the tracheostomy tube could be inducing reflex mucus hypersecretion. , 1977b). Material obtained from bronchial lavage is suitable for chemical analysis but unsuitable for rheological studies.

Terbutaline, a selective |3 agonist increases ciliary activity of h u m a n bronchial epithelium in vitro (Clarke and Lopez-Vidriero, 1983). M o r e studies are needed for a better understanding of control of ciliary activity in man. 2 Intercellular junctions Functional and ultrastructural studies on secretory epithelium suggest that the specificity of water and ion transport is a consequence of the physical characteristics 26 Lung secretions of the intercellular junctions (Oschman and Berridge, 1971).

Immunoglobulins, in particulage IgA dimer (10S), IgM and IgE are locally produced by plasma cells and mast cells located in the mucosa, while IgA (7S) and IgG derive mainly from tissue fluid transudate. Proteins play several roles in the airways, some influence viscoelastic properties by interacting with other macromolecules, others protect the airways against infection or damage by proteases. , 1982; Bhaskar and Reid, 1982). Neutral lipids, phospholipids and glycolipids have been identified but very little is known about their origin and functions.

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Aerosols and the Lung. Clinical and Experimental Aspects by Stewart W. Clarke


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